SULM – Schweizerische Union für Labormedizin | Union Suisse de Médecine de Laboratoire | Swiss Union of Laboratory Medicine

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G Tamaro, S Parco, G Tonini, F Gonano*

1IRCCS Burlo Garofolo-Trieste-Italy, 2*University of Udine-Italy

Glycation of proteins is a relevant factor in the pathogenesis of cardiovascular diseases. In diabetic patients the high level of glucose causes an increased glycative stress involving the most important lipoproteins. In a previous study we demonstrated that in children with insulin-dependent diabetes mellitus (IDDM) the Apolipoprotein A1/B-100 ratio is statistically significantly lower than in a control group of the same age (0.91 vs. 1.42). This datum was due to an increase Apolipoprotein B-100 (Apo B-100) serum level, and we supposed that the possible cause was the glycation of Apo B-100 with an alteration of its catabolism. We subsequently studied 33 children with IDDM and 13 healthy controls. Patients and controls differed by the traditional parameters of glycemic controls, such as fructosamine and glycated hemoglobin. By a combinated method of affinity chromatography and immunonefelometry we dosed total and glycated fraction of Apo B-100 and lipoprotein a (Lpa). The percentage of glycated fraction was statistically different for Apo B-100 between patients and controls (7.48, s.d. 3.93 vs. 4.77, s.d. 1.76; p < 0.005). A difference was measured also for Lp(a)(5.10, s.d. 4.78 vs. 3.61, s.d. 4.69) but it was not statistically significant (p=0.46). We suppose that this is due to the skewed and not Gaussian distribution of the Lp(a) serum values in the populations. Our results confirm the rilevance of glycation of Apo B-100 and Lp(a) in IDDM children. Apo B-100 and Lp(a) are both involved in lipids metabolism. Apo B-100 and Lp(a) are both involved in lipids metabolism. The high level of glycated fraction is an important factor of elevated cardiovascular risk in these patients.

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