SULM – Schweizerische Union für Labormedizin | Union Suisse de Médecine de Laboratoire | Swiss Union of Laboratory Medicine

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A. Sapunar1 , J. Markic2 , V. Krzelj2 , N. Bosnjak1

1Department of medical Laboratory Diagnostics, University Hospital Split,Split, Croatia, 2Pediatric Clinic, University Hospital Split, Split, Croatia

The objective of this study was to determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among the population of the city of Komiza on the island Vis, part of a region of Middle Dalmatia, which has been reported as a place with several cases of favism.(1,2)
In order to determine it, we performed a population screening using the fluorescent spot test.(3) Fluorescence readings were performed at the beginning and following 5, 10 and 20 min of incubation and were classified into three groups: bright fluorescence, weak fluorescence and no fluorescence. All men found to be deficient by this method were tested with a confirmatory quantitative spectrophotometric method.
Of the 302 males tested, 18 (5,96%) were G6PD deficient. It has been found that the prevalence rate of G6PD deficiency among men from Komiza is significantly higher (p < 0,001) compared with the prevalence rate in the region of Middle Dalmatia (0,75% in males, 0,14% in females).
Based on these findings it is recommended that infants originating from the island of Vis should be included into a screening program for G6PD deficiency.


I.Ruzdic,S.Vuletic J. Med. Genet.1969;6:281
3. E.Beutler,K.G.Blume,J.C.Kaplan,G.W.Lohr
B.Ramot,W.N.Valentine. Br.J.Hematol 1979;43:465


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