SULM – Schweizerische Union für Labormedizin | Union Suisse de Médecine de Laboratoire | Swiss Union of Laboratory Medicine

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J Lazić1 , V Rumenjak1

1Department for Medical Laboratory Diagnostics and Trasfuziology, Sveti Duh General Hospital, Zagreb, Croatia

The aim of this clinical study was to evaluate the role of PCT testing in diagnosing of severe systemic bacterial infection and it’s correlation with the routine laboratory parameters (White Blood Cells Count-WBC and C Reactive Protein-CRP concentration).
Methods: 85 patients have been included in the study. All were admitted to the intensive care unit under the clinical diagnosis of severe systemic bacterial infection. Upon admittance all the patients were ordered WBC, CRP and PCT testing. PCT concentration was determined by an immunochromatografic test for the semiquantitative detection of PCT from serum samples (BRAMS-PCT-Q). PCT, WBC and CRP testing results of each patient were grouped as follows: (1) PCT, WBC, CRP within reference values; (2) PCT>2ng/ml, CRP>10mg/L, WBC>10 x 109/L– all above reference range; (3) WBC and CRP above, PCT within ref. range; (4) PCT and CRP above, WBC within ref. range; (5) PCT and WBC within, CRP above ref. range; (6) Group PCT above, WBC and CRP within ref. range.
Results: 45 patients have been confirmed with systemic bacterial infection by other diagnostic testing procedures. In all of the 45 patients PCT has been above reference range: alone in 4.4% (n=2) of patients, together with CRP in 33.3% (n=15) of patients and in combination with CRP and WBC in 62.2% (n=28) of patients. The remaining 40 patients have been diagnosed with conditions other then bacterial infection and all had PCT within reference range. 47.5% (n=19) of those patients had routine laboratory parameters (CRP and WBC) above ref. range, 37.5% (n=15) of those patients had (CRP) above while (WBC) within ref. range, and 15% (n=6) of patients had both (WBC, CRP) within ref. range.
Conclusion: PCT is a useful innovative parameter in systemic bacterial infection diagnostics providing the clinicians with high diagnostic specificity especially in cases with WBC and CRP within ref. range, hard to interpret or false positive when no systemic bacterial infection is present.

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