SULM – Schweizerische Union für Labormedizin | Union Suisse de Médecine de Laboratoire | Swiss Union of Laboratory Medicine

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K Kljaic1 , J Dovhanj2 , A Vcev3

1Department of Chemistry and Biochemistry, School of Medicine, University of Zagreb, Salata 3b,Zagreb, Croatia, 2Department of Chemistry and Biochemistry, School of Medicine,University of Osijek, Huttlerova 4, Osijek, Croatia, 3Internal Clinic, Clinical Hospital Osijek, Huttlerova 4, Osijek, Croatia

The study investigated the connection between the gastric mucosal damage
and the activity of antioxidant enzymes glutathione peroxidase (GPX) and glutathione reductase (GR) in patients with Helicobacter pylori-induced chronic gastritis and peptic ulcer disease.
The investigation comprised 31 patients with chronic gastritits , 25 with gastric ulcer and control group with 23 healthy people. We excluded patients with nonulcer dyspepsia and who had received non-steroidal anti- inflammatory agents .
All patient underwent a gastric endoscopy and tissue sample were collected from gastric antrum and corpus. Histologic examinations were performed by Giemsa staining for detection of Helicobacter pylori. The urea breath test was performed in the control group. Gastric histology of infected host was reviewed using the updated Sydney System.
The enzyme activity ( GPX, GR ) was determined spectrophotometrically in erythrocytes and whoole blood of all patients and control group.
Glutathione peroxidase of the Helicobacter pylori positive patients is significantly(p < 0,05) lowered in correlation with the control group. Glutathione reductase of Helicobacter pylori positive patients is significantly higher in correlation with the control group. GPX activity in patients with gastritis is significantly (p < 0,05) lowered in correlation with the patients with ulcer disease.
Our results showed that the activity of these enzymes changes, depending on the degree of the inflammation and gastric mucosal damage in gastritis and peptic ulcer disease. There is probably a causative correlation between the presence of Helicobacter pylori and free radicals .

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