SULM – Schweizerische Union für Labormedizin | Union Suisse de Médecine de Laboratoire | Swiss Union of Laboratory Medicine

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L de la Fontaine1 , M Schwarz2 , H Plischke1 , P Zill2 , R Gruber 1

1Rheumaeinheit des Klinikums der Ludwig-Maximilian-Universität, Medizinische Poliklinik - Innenstadt, Pettenkoferstr. 8a, 80336 München, 2Klinikum der Universität, Klinik für Psychiatrie und Psychotherapie, Nussbaumstr. 7, 80336 München

Objektive : CD14 , the monocyte receptor for bacterial lipopolysaccharide (LPS), is an important mediator of inflammatory process. As the C to T exchange at position -159 in the promotor region of the CD14 gene on chromosome 5q31 leads to enhanced expression of CD14 in monocytes this could be a canditate gene for susceptibility to rheumatoid arthritis (RA). We therefore investigated, if this single nucleotide polymorphism (SNP) could be a risk faktor for the developement of RA or has any influence on serological activity parameters like rheumatoid factor (RF), anti-citrullin-antibodies (CCP), anti-nuclear antibodies (ANA) and CRP.
Patients and Methods: 130 Caucasians suffering from RA, diagnosed according to the revised classification criteria of the American College of Rheumatology and 130 healthy Caucasian individuals were genotyped for the polymorphism using PCR. Serum parmeters were assessed using standard laboratory tests. Result: Forty (31%) of our RA patients and 39 (30%) of the controls were genotyped as CC; 71 (55%) patients and 67 (52%) controls were heterozygous, whereas 19 (15%) patients and 24 (19%) control persons showed the TT genotype (p=0.7). Accordingly, the frequency of the C allele was 0.58 in patients and 0.56 in control subjects; for the T allele it was 0.42 in patients and 0.44 in healthy controls (p=0.8). Thus the CD14 -159 genotype distribution and allele frequencies were not different between patients and controls. There was also no significant difference in genotype distribution within the subgroups of RA patients categorized according to serological parameters.
Conclusion: Altogether, we did not observe an evidence for the association between the CD14 C159T polymorphism with increased risk for the development of RA. Also no influence of the SNP on serological activity parameters were found, suggesting that this base exchange has no relevance for the course and severity of rheumatoid arthritis.

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