SULM – Schweizerische Union für Labormedizin | Union Suisse de Médecine de Laboratoire | Swiss Union of Laboratory Medicine

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J. Dvorakova1 , J. Hyanek1 , L. Taborsky1 , L. Dubska1 , H. Pejznochova1 , M. Vodickova1

1Dept. Clin. Biochemistry, Hospital Na Homolce, Prague, Czech Republic

The aim of our study was to evaluate the causes of hyperhomocysteinaemia /HHcy/ in patients suffering from cardiovascular diseases.
The study included 50 patients (32M, 18F) with cardiovascular disease and 40 controls (22M, 18F). Besides clinical examination and routine analyses we determined plasma total homocysteine /tHcy/, serum folate, vitamin B12, B6 and MTHFR 677C-T mutation.
Among the patients with HHcy 36% presented the TT genotype, in the control group 20%. We did not find any differences between the levels of tHcy in TT, CT, and CC genotype (23.8 +/- 7.7 umol/l) in patients. The levels of serum folate were significantly lower in TT genotype than in CC genotype /p < 0.05/ in both groups. Other causes of HHcy were: smoking (20%), vitamin B12 depletion (12%), high alcohol intake (6%), renal disease (8%), hypothyroid state (4%), fibrates (8%).
Conclusions: Elevated tHcy levels in patients with vascular disease are the result of a cluster of factors (genetic, lifestyle, drugs, diseases...). MTHFR (677 C-T) polymorphism may provoke HHcy mainly in individuals with low folate status.


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